Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have
been examined extensively due to the potential harmful effects in the health of human …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

The hypothesis of fetal origins of adult disease posits that early developmental exposures
involve epigenetic modifications, such as DNA methylation, that influence adult disease …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Bisphenol A (BPA), initially designed, like diethylstilbestrol, as a synthetic estrogen, has
been rapidly and widely used for its cross-linking properties in the manufacture of …

Traditional studies on the combined effects of genetics and the environment on individual
variation in disease susceptibility primarily focus on single nucleotide polymorphisms that …

This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

Dietary and other environmental factors induce epigenetic alterations which may have
important consequences for cancer development. This chapter summarizes current …

The synthetic estrogen diethylstilbestrol (DES) is a potent perinatal endocrine disruptor. In
humans and experimental animals, exposure to DES during critical periods of reproductive …