Epithelial ovarian cancer experimental models

E Lengyel, JE Burdette, HA Kenny, D Matei, J Pilrose… - Oncogene, 2014 - nature.com
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …

The chicken model of spontaneous ovarian cancer

AM Hawkridge - PROTEOMICS–Clinical Applications, 2014 - Wiley Online Library
The chicken is a unique experimental model for studying the spontaneous onset and
progression of ovarian cancer (OVC). The prevalence of OVC in chickens can range from 5 …

Causes of mortality in backyard chickens in northern California: 2007–2011

A Mete, F Giannitti, B Barr, L Woods… - Avian …, 2013 - meridian.allenpress.com
SUMMARY A 5-yr retrospective study was conducted to characterize the spectrum of
diseases causing mortality in 1301 backyard chickens submitted to the California Animal …

[HTML][HTML] Histology of the Ovary of the Laying Hen (Gallus domesticus)

KD Apperson, KE Bird, G Cherian, CV Löhr - Veterinary Sciences, 2017 - mdpi.com
The laying hen (Gallus domesticus) is a robust animal model for epithelial ovarian cancer.
The use of animal models is critical in identifying early disease markers and developing and …

[HTML][HTML] Evidence for the conservation of biological activity of ovulation-inducing factor in seminal plasma

OA Bogle, MH Ratto, GP Adams - Reproduction, 2011 - rep.bioscientifica.com
After a long period of spermatogenesis (several weeks to months), marine fish spermatozoa
are delivered at male spawning in seawater (SW) at the same time as ova. In some fish …

Chemopreventive and antitumor efficacy of curcumin in a spontaneously developing hen ovarian cancer model

K Sahin, C Orhan, M Tuzcu, N Sahin, H Tastan… - Cancer Prevention …, 2018 - AACR
We investigated the effect of daily dietary curcumin intake on the development and
progression of spontaneous ovarian cancer in a galline (hen) model, as the chicken is the …

[HTML][HTML] Selenium Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer

Y Yu-Rice, SL Edassery, N Urban… - Reproduction …, 2017 - ncbi.nlm.nih.gov
Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to
Selenium Binding Protein 1 (SBP1), an autoantibody we identified in patients with premature …

A review of principal studies on the development and treatment of epithelial ovarian cancer in the laying hen Gallus gallus

P Pal, KN Starkweather, KH Hales… - Comparative …, 2021 - ingentaconnect.com
Often referred to as the silent killer, ovarian cancer is the most lethal gynecologic
malignancy. This disease rarely shows any physical symptoms until late stages and no …

[HTML][HTML] Spontaneous transformation of murine oviductal epithelial cells: a model system to investigate the onset of fallopian-derived tumors

MP Endsley, G Moyle-Heyrman, S Karthikeyan… - Frontiers in …, 2015 - frontiersin.org
High-grade serous carcinoma (HGSC) is the most lethal ovarian cancer histotype. The
fallopian tube secretory epithelial cells (FTSECs) are a proposed progenitor cell type …

[HTML][HTML] Comparative transcriptomic study on the ovarian cancer between chicken and human

G Zhu, X Wang, Y Wang, T Huang, X Zhang, J He… - Poultry Science, 2024 - Elsevier
The laying hen is the spontaneous model of ovarian tumor. A comprehensive comparison
based on RNA-seq from hens and women may shed light on the molecular mechanisms of …