Acquired sensorineural hearing loss is one of the most prevalent chronic diseases, and
aging and acoustic overexposure are common contributors. Decades of study in animals …

The diagnostics of inner ear diseases are primarily functional, but there is a growing interest
in inner ear biomarkers. The present scoping review aimed to elucidate gaps in the literature …

The exact neurophysiological basis of chronic tinnitus, which affects 10-15% of the
population, remains unknown and is controversial at many levels. It is an open question …

For successful future therapeutic strategies for tinnitus and hyperacusis, a subcategorization
of both conditions on the basis of differentiated neural correlates would be of invaluable …

Spread of antimicrobial resistance and shortage of novel antibiotics have led to an urgent
need for new antibacterials. Although aminoglycoside antibiotics (AGs) are very potent anti …

USH2A variants are the most common cause of Usher syndrome type 2, characterized by
congenital sensorineural hearing loss and retinitis pigmentosa (RP), and also contribute to …

Background: Hyperacusis is intolerance of certain everyday sounds that causes significant
distress and impairment in social, occupational, recreational, and other day-to-day activities …

Objectives: Serological biomarkers, common to many areas of medicine, have the potential
to inform on the health of the human body and to give early warning of risk of compromised …

Novel hearing therapeutics are rapidly progressing along the innovation pathway and into
the clinical trial domain. Because these trials are new to the hearing community, they come …

Nitric oxide (NO) activates the NO-sensitive soluble guanylate cyclase (NO-GC, sGC) and
triggers intracellular signaling pathways involving cGMP. For survival of cochlear hair cells …