Bicalutamide is a nonsteroidal pure antiandrogen given at a dosage of 150mg once daily as
monotherapy for the treatment of early (localised or locally advanced) nonmetastatic …

All forms of androgen-deprivation therapy, including finasteride, induce distinctive histologic
changes in benign and neoplastic prostatic epithelial cells, including cytoplasmic clearing …

Exposure to environmental chemicals known as endocrine disruptors (EDs) is in many
cases associated with an unpredictable hazard for wildlife and human health. The …

The mechanisms underlying the progression of prostate cancer to a state of resistance to
hormone ablation remain poorly understood. Here, we have investigated the relationship …

This is a mini-review summarizing recent findings on the effect of flutamide (FLUT), an anti-
androgenic toxicant, on the mouse testis, particularly on the ectoplasmic specialization (ES) …

Prostate cancer chemoprevention can be described as the administration of natural products
and pharmaceutical agents that inhibit one or more steps in the natural history of prostatic …

Currently under development for therapeutic purposes in human medicine, non‐steroidal
selective androgen receptor modulators (non‐steroidal SARMs) are also known to impact …

Previous reports have revealed that estrogen agonists or anti-androgenic chemicals induce
abnormal spermiogenesis in rodents. In the seminiferous epithelium, the apical ectoplasmic …

Flutamide (Flu) is an anti-androgenic compound that disrupts development of male
androgen-dependent tissues. The purpose of the present study was to investigate the effects …

Flutamide (FLUT) has potent anti-androgenic activity and is used in the medical field and in
a screening test to detect endocrinologically active compounds. Our previous study …