[HTML][HTML] Phage Therapy: Targeting Intestinal Bacterial Microbiota for Treatment of Liver Diseases

J Fujiki, B Schnabl - JHEP Reports, 2023 - Elsevier
Phage therapy has been overshadowed by antibiotics for decades. However, it has been
revitalized as a powerful approach against antimicrobial-resistant bacteria. As the bacterial …

Fitness trade-offs between phage and antibiotic sensitivity in phage-resistant variants: molecular action and insights into clinical applications for phage therapy

J Fujiki, K Nakamura, T Nakamura, H Iwano - International Journal of …, 2023 - mdpi.com
In recent decades, phage therapy has been overshadowed by the widespread use of
antibiotics in Western countries. However, it has been revitalized as a powerful approach …

Phage treatment of Pseudomonas aeruginosa yields a phage-resistant population with different susceptibility to innate immune responses and mild effects on …

T Olszak, D Augustyniak, I García-Romero… - Microbiological …, 2024 - Elsevier
In this study, we have investigated innate immune activation capacity and metabolic features
of a population of P. aeruginosa PAO1 phage-resistant mutants with diverse genetic …

More evolvable bacteriophages better suppress their host

EK Horwitz, HM Strobel, J Haiso… - Evolutionary …, 2024 - Wiley Online Library
The number of multidrug‐resistant strains of bacteria is increasing rapidly, while the number
of new antibiotic discoveries has stagnated. This trend has caused a surge in interest in …

Coevolutionary phage training and Joint application delays the emergence of phage resistance in Pseudomonas aeruginosa

M Wang, J Wei, L Jiang, L Jiang, J Zhang, X He… - Virus …, 2023 - academic.oup.com
Antibiotic-resistant bacteria are current threats to available antibiotic therapies, and this has
renewed interest in the therapeutic use of phage as an alternative. However, development of …

[HTML][HTML] Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes

A Lucia-Sanz, S Peng, CYJ Leung, A Gupta, JR Meyer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The enormous diversity of bacteriophages and their bacterial hosts presents a significant
challenge to predict which phages infect a focal set of bacteria. Infection is largely …

Development and Encapsulation of a Multi-Receptor Phage Cocktail Against Salmonella for Poultry Food Safety and Multi-Omics Characterization of Phage …

CE Martinez-Soto - 2024 - atrium.lib.uoguelph.ca
Salmonella is one of the most prevalent food-borne bacterial pathogens worldwide, causing
human gastroenteritis. Using broad-host range lytic bacteriophages (phages) as biocontrol …

Bacteriophage therapy for multi-drug resistant Staphylococcus aureus infections within the airways

JJ Iszatt - 2023 - espace.curtin.edu.au
This thesis supports the potential of phages in treating respiratory infections caused by
Staphylococcus aureus bacteria, including MRSA. Phages Koomba kaat 1 and Biyabeda …