[HTML][HTML] Molecular and cellular mechanisms of pulmonary fibrosis

NW Todd, IG Luzina, SP Atamas - Fibrogenesis & tissue repair, 2012 - Springer
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Glucocorticosteroids: current and future directions

PJ Barnes - British journal of pharmacology, 2011 - Wiley Online Library
Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

Inhaled corticosteroids in COPD and the risk of serious pneumonia

S Suissa, V Patenaude, F Lapi, P Ernst - Thorax, 2013 - thorax.bmj.com
Background Inhaled corticosteroids (ICS) are known to increase the risk of pneumonia in
patients with chronic obstructive pulmonary disease (COPD). It is unclear whether the risk of …

Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns

D Price, D West, G Brusselle… - … journal of chronic …, 2014 - Taylor & Francis
Background Despite the availability of national and international guidelines, evidence
suggests that chronic obstructive pulmonary disease (COPD) treatment is not always …

Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol–fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a …

CF Vogelmeier, ED Bateman, J Pallante… - The Lancet …, 2013 - thelancet.com
Background QVA149 is an inhaled fixed-dose combination therapy under development for
the treatment of chronic obstructive pulmonary disease (COPD). It combines indacaterol (a …

Inhaled corticosteroids and the risks of diabetes onset and progression

S Suissa, A Kezouh, P Ernst - The American journal of medicine, 2010 - Elsevier
BACKGROUND:: Systemic corticosteroids are known to increase diabetes risk, but the
effects of high-dose inhaled corticosteroids are unknown. We assessed whether the use and …

[HTML][HTML] Inhaled corticosteroids

PJ Barnes - Pharmaceuticals, 2010 - mdpi.com
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress
inflammation mainly by switching off multiple activated inflammatory genes through …

LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD

N Zhong, C Wang, X Zhou, N Zhang… - … journal of chronic …, 2015 - Taylor & Francis
Background The current Global initiative for chronic Obstructive Lung Disease (GOLD)
treatment strategy recommends the use of one or more bronchodilators according to the …

Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive …

N Horita, A Goto, Y Shibata, E Ota… - Cochrane Database …, 2017 - cochranelibrary.com
Background Three classes of inhaler medications are used to manage chronic obstructive
pulmonary disease (COPD): long‐acting beta‐agonists (LABA), long‐acting muscarinic …

The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK

G Brusselle, D Price, K Gruffydd-Jones… - … journal of chronic …, 2015 - Taylor & Francis
Background Real-world prescription pathways leading to triple therapy (TT)(inhaled
corticosteroid [ICS] plus long-acting β2-agonist bronchodilator [LABA] plus long-acting …