Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …

During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …

The expansion of introns within mammalian genomes poses a challenge for the production
of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich …

It is unclear how various factors functioning in the transcriptional elongation by RNA
polymerase II (RNA Pol II) cooperatively regulate pause/release and productive elongation …

The pause-release model of transcription proposes that 40–100 bases from the start site
RNA Pol II pauses, followed by release into productive elongation. Pause release is …

Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including
Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective …

Pleiotropic transcription regulator RNA polymerase II (Pol II)–associated factor 1 (PAF1)
governs multiple transcriptional steps and the deposition of several epigenetic marks …

In eukaryotes, all genetic processes take place in the cell nucleus, where DNA is packaged
as chromatin in'beads-on-a-string'nucleosome arrays. RNA polymerase II (RNAPII) …