The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca2+ Channels and Mitochondrial Function in Cardiomyocytes

S Mahmoodzadeh, E Dworatzek - Frontiers in Endocrinology, 2019 - frontiersin.org
Numerous epidemiological, clinical, and animal studies showed that cardiac function and
manifestation of cardiovascular diseases (CVDs) are different between males and females …

Female heart health: is GPER the missing link?

L Groban, QK Tran, CM Ferrario, X Sun… - Frontiers in …, 2020 - frontiersin.org
The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor
that mediates non-genomic actions of the primary female sex hormone 17β-estradiol …

Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway

Z Feng, C Wang, Y Jin, Q Meng, J Wu… - Pharmaceutical …, 2021 - Taylor & Francis
Context The effect of kaempferol, a regulator of oestrogen receptors, on atherosclerosis (AS)
and the underlying mechanism is elusive. Objective To explore the effect and mechanism of …

Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases

L Jiao, JO Machuki, Q Wu, M Shi, L Fu… - American Journal …, 2020 - journals.physiology.org
Estrogen deficiency is considered to be an important factor leading to cardiovascular
diseases (CVDs). Indeed, the prevalence of CVDs in postmenopausal women exceeds that …

Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis

L Medzikovic, L Aryan, M Eghbali - Journal of Molecular Medicine, 2019 - Springer
Sex differences are evident in the pathophysiology of heart failure (HF). Progression of HF is
promoted by cardiac fibrosis and no fibrosis-specific therapies are currently available. The …

The Relationship between cadmium exposure and mortality in postmenopausal females: A cohort study of 2001–2018 NHANES

JW Shi, DX Fan, MQ Li - Nutrients, 2023 - mdpi.com
Cadmium is one of the most harmful elements to human health, and the health of
postmenopausal females is an important public health issue. However, the correlation …

Sex as biological variable in cardiac mitochondrial bioenergetic responses to acute stress

SR Scott, K Singh, Q Yu, CK Sen, M Wang - International journal of …, 2022 - mdpi.com
Cardiac dysfunction/damage following trauma, shock, sepsis, and ischemia impacts clinical
outcomes. Acute inflammation and oxidative stress triggered by these injuries impair …

Lung cancer screening CT-based coronary artery calcification in predicting cardiovascular events: a systematic review and meta-analysis

L Fan, K Fan - Medicine, 2018 - journals.lww.com
Background: Coronary artery calcificition (CAC) is a well-established predictor of
cardiovascular events (CVEs). We aimed to evaluate whether lung cancer screening …

The effects of alone and combination tamoxifen, raloxifene and estrogen on lipid profile and atherogenic index of ovariectomized type 2 diabetic rats

MN Ebrahimi, M Khaksari, G Sepehri, GA Karam… - Life Sciences, 2020 - Elsevier
Introduction The cardiovascular dysfunctions in postmenopausal diabetic women increase
relative to premenopausal women. In this study we evaluated protective effects of selective …

Sex-specific determinants of coronary artery disease and atherosclerotic risk factors: estrogen and beyond

RD Feldman - Canadian Journal of Cardiology, 2020 - Elsevier
The way we view coronary artery disease in women has changed dramatically over the past
decades. From an initial perspective that coronary artery disease was a male disorder and …