Statins are well known competitive inhibitors of hydroxymethylglutaryl-CoA reductase
enzyme (HMG-CoA reductase), thus traditionally used as cholesterol-lowering agents. In …

Statins have pleiotropic properties and might exert an effect even in the field of cancer.
Statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase …

Purpose Treating small-cell lung cancer (SCLC) remains a therapeutic challenge.
Experimental studies show that statins exert additive effects with agents, such as cisplatin, to …

Objective The statin family of cholesterol-lowering drugs has been shown to induce tumor-
specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway …

Purpose Increasing evidence indicates that statin use may reduce mortality from prostate
cancer. In this work, we examined whether postdiagnosis statin use was associated with …

Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …

Background: Mixed evidence exists regarding the effects of statins among men with prostate
cancer. We aimed to determine the association between statin use and clinical outcomes in …

Background Studies have conflicting results regarding the association between statin use
and biochemical recurrence for prostate cancer (PCa). A limited number of studies …

Background Many studies have recently reported the association of concomitant
medications with the response and survival in patients with non-small-cell lung cancer …

The aim of this study is to provide an overview and understand the strength of evidence and
the extent of potential biases and the validity of claimed associations between the use of …