Background: The impact of statin use on biochemical recurrence (BCR) in patients treated
with radical prostatectomy (RP) remains controversial. Methods: We retrospectively …

Background: Observational studies suggest potential chemopreventive benefits of statins on
prostate cancer outcomes, but data on the impact of postdiagnostic use are sparse …

The present study was conducted to investigate the effect of γ-radiation alone or combined
with a cytotoxic drug, simvastatin, on viability and cell cycling of a myeloma cell line. P3NS1 …

Studies have reported that atorvastatin (ATO) may increase the radiosensitivity of malignant
cells. However, the influence of ATO on reactive oxygen species (ROS) levels before and …

Purpose Numerous studies have produced conflicting findings regarding the efficacy of
statins in prostate cancer treatment. Our objective was to examine the correlation between …

Background and objective Chuquiraga spinosa Lessing (ChS) has shown protective effect
on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats. Currently, statins are …

Results 175 patients were treated with statins (65.3% with a dose≤ 20 mg/day) and 70 with
metformin (75.7% with a dose≤ 1700 mg/day). Median follow-up was 88 months (1–194) …

The treatment of castration-resistant (CR) prostate cancer (PCa) is limited. A sub-population
of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) …

Purpose Cardiovascular disease (CVD) is a major non-cancer cause of mortality among
cancer survivors, and statin therapy is the mainstay of cardiovascular risk management …

Objectives To assess the impact of statin use on overall and time to biochemical failure
following primary treatment of localized prostate cancer (PCa). Subjects/patients and …