Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1,
JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK …

The targeted therapy is a groundbreaking innovation in cancer treatment. Among the
receptor tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered enormous …

Highlights•Review of function-site interaction fingerprints for drug discovery.•Study of the
polypharmacology of kinase inhibitors.•Kinase allosteric and covalent inhibitors.Determining …

During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …