In this study, the new catalytic applications of the dendritic Fe 3 O 4@ SiO 2@ KCC-1@
MPTMS@ Cu II mesoporous nanocomposite have been introduced for the green one-pot …

Pancreatic cancer is a deadly disease with an extremely poor 5-year survival rate due to
treatment resistance and late-stage detection. Despite numerous years of research and …

Chronic myeloid leukemia (CML) is a malignant disease of the hematopoietic system with
crucial pathogenic protein named BCR-ABL, which endangers the life of patients severely …

Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase
(BChE) have been considered target enzymes of depression and neurodegenerative …

Kinases are among the most important families of biomolecules and play an essential role in
the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological …

Cancer is a multifactorial disorder with extremely complex genetics and progression. The
major challenge in cancer therapy is the development of cancer resistance and relapse …

Targeting the kinases MNK1 and MNK2 has emerged as a valuable strategy in oncology.
However, most of the advanced inhibitors are acting in an adenosine triphosphate (ATP) …

The Janus kinase (JAK) family enzymes are non-receptor tyrosine kinases that
phosphorylate cytokine receptors and signal transducer and activator of transcription (STAT) …

Great needs always motivate the birth and development of new disciplines and tools. Here
we propose in vitro BioTransformation (ivBT) as a new biomanufacturing platform, between …

More than 500 kinases are implicated in the control of most cellular process in mammals,
and deregulation of their activity is linked to cancer and inflammatory disorders. 80 clinical …