Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes,
very few agents have been introduced during the past 20 years. The thiazolidinediones …

Insulin resistance in humans is not always accompanied by obesity, since severe insulin
resistance also characterizes patients lacking subcutaneous fat such as those with HAART …

OBJECTIVE To assess whether clinical characteristics and simple biomarkers of β-cell
failure are associated with individual variation in glycemic response to GLP-1 receptor …

The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose
homeostasis and lipid metabolism. This study investigated the effects of administration of a …

The pathogenesis of type 2 diabetes involves both insulin resistance and defects in insulin
secretion. Although obesity and physical inactivity have precipitated the epidemic of type 2 …

The present study investigated the effect of resveratrol on the electrophysiology and insulin
secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin …

Type 2 diabetes mellitus and obesity are the most frequent endocrine-metabolic diseases in
the world and their pathogenic basis are characterized by insulin resistance and insulin …

Obesity is associated with an increased risk for insulin resistance, a state characterized by
impaired responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids …

Glucose-dependent insulinotropic polypeptide (GIP or gastric inhibitory polypeptide) is a 42-
amino-acid hormone, secreted from the enteroendocrine K cells, which has insulin-releasing …

Human type 1 diabetes mellitus is a chronic autoimmune disease characterized by the
selective loss of insulin-producing β-cells in pancreatic islets of genetically susceptible …