Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

The cardiovascular complications contribute to a majority of diabetes associated morbidity
and mortality, accounting for 44% of death in those patients with type 1 diabetes mellitus …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of
plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Cardiac autonomic neuropathy (CAN) is an often overlooked and common complication of
diabetes mellitus. CAN is associated with increased cardiovascular morbidity and mortality …

Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …

The leading cause of death in diabetic patients is cardiovascular disease; diabetic
cardiomyopathy is typified by alterations in cardiac morphology and function, independent of …