RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Abstract Nickel (II), copper (II) and zinc (II) complexes with the same ligands normally display
analogous coordination geometry and binding mode toward DNA. However, although …

The surprising discovery that RNAs are the predominant gene products to emerge from the
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …

Modification of SMN2 exon 7 (E7) splicing is a validated therapeutic strategy against spinal
muscular atrophy (SMA). However, a target-based approach to identify small-molecule E7 …

Synthetic small molecules modulating RNA structure and function have therapeutic potential
for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) …

We report here the nuclear magnetic resonance 19F screening of 14 RNA targets with
different secondary and tertiary structure to systematically assess the druggability of RNAs …

Fluorescent indicator displacement (FID) assays are an advantageous approach to convert
receptors into optical sensors that can detect binding of various ligands. In particular, the …

The increasing appreciation for the crucial roles of RNAs in infectious and non-infectious
human diseases makes them attractive therapeutic targets. Coding and non-coding RNAs …

RNA is an important therapeutic target but information about RNA–ligand interactions is
limited. Here, we report a screening method that probes over 3,000,000 combinations of …