[HTML][HTML] Targeting noncoding RNAs in disease
BD Adams, C Parsons, L Walker… - The Journal of …, 2017 - Am Soc Clin Investig
Many RNA species have been identified as important players in the development of chronic
diseases, including cancer. Over the past decade, numerous studies have highlighted how …
diseases, including cancer. Over the past decade, numerous studies have highlighted how …
[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
[HTML][HTML] Challenges identifying efficacious miRNA therapeutics for cancer
M Segal, FJ Slack - Expert opinion on drug discovery, 2020 - Taylor & Francis
MicroRNAs are a class of small non-coding RNAs (22-23 nucleotides), which regulate gene
expression at the posttranscriptional level and play key roles in tumorigenesis and other …
expression at the posttranscriptional level and play key roles in tumorigenesis and other …
MicroRNAs in the p53 network: micromanagement of tumour suppression
H Hermeking - Nature reviews cancer, 2012 - nature.com
In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …
Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer
MicroRNAs (miRNAs) are short, noncoding RNAs that regulate gene expression by
suppressing mRNA translation and reducing mRNA stability. A miRNA can potentially bind …
suppressing mRNA translation and reducing mRNA stability. A miRNA can potentially bind …
[HTML][HTML] MicroRNA-34a: a potential therapeutic target in human cancer
XJ Li, ZJ Ren, JH Tang - Cell death & disease, 2014 - nature.com
MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by
binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were …
binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were …
MicroRNA-34a plays a key role in cardiac repair and regeneration following myocardial infarction
Rationale: In response to injury, the rodent heart is capable of virtually full regeneration via
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …
[HTML][HTML] RNA-based therapies: A cog in the wheel of lung cancer defense
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
The roles of miRNAs as potential biomarkers in lung diseases
MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of
gene expression, modulate almost all biological process and are essential for maintaining …
gene expression, modulate almost all biological process and are essential for maintaining …
[HTML][HTML] MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications
C Stahlhut, FJ Slack - Genome medicine, 2013 - Springer
MicroRNAs (miRNAs) have emerged as key genetic regulators of a wide variety of biological
processes, including growth, proliferation, and survival. Recent advances have led to the …
processes, including growth, proliferation, and survival. Recent advances have led to the …