Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future

P Greco, G Nencini, I Piva, M Scioscia, CA Volta… - Acta Neurologica …, 2020 - Springer
Hypoxic–ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage
that is caused by a lack of oxygen to the brain during neonatal period. The incidence is …

Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

[HTML][HTML] Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study

PJ Lally, P Montaldo, V Oliveira, A Soe… - The Lancet …, 2019 - thelancet.com
Background In neonatal encephalopathy, the clinical manifestations of injury can only be
reliably assessed several years after an intervention, complicating early prognostication and …

Management and investigation of neonatal encephalopathy: 2017 update

K Martinello, AR Hart, S Yap, S Mitra… - Archives of Disease in …, 2017 - fn.bmj.com
This review discusses an approach to determining the cause of neonatal encephalopathy,
as well as current evidence on resuscitation and subsequent management of hypoxic …

Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates

J Nair, VHS Kumar - Children, 2018 - mdpi.com
Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment

EP Yıldız, B Ekici, B Tatlı - Expert review of neurotherapeutics, 2017 - Taylor & Francis
Introduction: Hypoxic ischemic encephalopathy (HIE) is the most important reason for
morbidity and mortality in term-born infants. Understanding pathophysiology of the brain …

High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: a phase II trial

YW Wu, AM Mathur, T Chang, RC McKinstry… - …, 2016 - publications.aap.org
OBJECTIVE: To determine if multiple doses of erythropoietin (Epo) administered with
hypothermia improve neuroradiographic and short-term outcomes of newborns with hypoxic …

New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy

S Victor, E Rocha-Ferreira, A Rahim, H Hagberg… - European journal of …, 2022 - Springer
Around 0.75 million babies worldwide suffer from moderate or severe hypoxic-ischemic
encephalopathy (HIE) each year resulting in around 400,000 babies with …

Neuroimaging in the term newborn with neonatal encephalopathy

JL Wisnowski, P Wintermark, SL Bonifacio… - Seminars in Fetal and …, 2021 - Elsevier
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates
with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few …

Neonatal encephalopathy and hypoxic–ischemic encephalopathy

AJ Gunn, M Thoresen - Handbook of clinical neurology, 2019 - Elsevier
Acute hypoxic–ischemic encephalopathy around the time of birth remains a major cause of
death and life-long disability. The key insight that led to the modern revival of studies of …