Methods: An anonymous online survey was distributed by e-mail to the orthopaedic
societies of all 50 states and several large private practices to assess practicing orthopaedic …

Neuropathic pain (NP) and its treatment are considered to constitute an unmet need, with a
high-multidimensional impact on society and the sufferer. The broad spectrum of opioid …

Background/Aims: Several factors influencing postoperative pain and the effect of opioid
analgesics have been investigated on an individual level. The aim of this study was to clarify …

Many genetic markers have been associated with variations in treatment response to
analgesics, but none have been assessed in the context of combination therapies. In this …

The study of sex-specific genetic associations with opioid response may improve the
understanding of inter-individual variability in pain treatments. We investigated sex-specific …

Background The purpose of this study is to determine whether pharmacogenetic testing
could be used to effectively customize postoperative pain medicine following total joint …

Background Pain can be a significant burden for patients with cancer and may have
negative effects on their quality of life. Opioids are potent analgesics and serve as a …

Cancer pain is the most feared symptom at end of life. Methadone has advantages over
other opioids but is associated with significant variability in clinical response, making dosing …

Background Opioids are used for the treatment of pain. However, 30–50% of patients have
insufficient effect to the opioid initially selected by the physician, and there is an urgent need …

Human studies on experimentally induced pain are of value to elucidate the genetic
influence on morphine analgesia under controlled conditions. The aim of this study was to …