Our aim was to describe the effect of dosing and genetic factors on sufentanil-and
midazolam-induced analgosedation and withdrawal syndrome (WS) in pediatric population …

Aim Cancer pain impairs not only physical functions but also social functions and roles.
Consequently, the overall health‐related quality of life of patients with cancer pain …

Purpose Different amounts of opioid are required for the relief of cancer pain in different
individuals, raising the possibility that genetic factors play a role. We tested the hypothesis …

In advanced cancer, pain is a poor prognostic factor, significantly impacting patients' quality
of life. It has been shown that up to 30% of cancer patients in Southeast Asian countries may …

Objectives Numerous in vitro studies have evaluated the influence of opioids on many
biological and immunological processes. The concentrations that have been used in these …

Prescribed chronic opioid therapy (COT) has dramatically increased over the past decade
with resultant startling increased mortality. 1 No doubt, a large portion of associated …

Adverse drug reactions (ADRs) are of major concern in drug safety. However, due to the
biological complexity of human systems, understanding the underlying mechanisms …

Background Laboratorians have the opportunity to help minimize the frequency of adverse
drug reactions by implementing pharmacogenomic testing and alerting care providers to …

Family and twin studies demonstrate that genetic factors determine 20-60% of the
vulnerability to opioid use disorder. However, the genes/alleles that mediate the risk of …

FOR MANY WHO HAVE worked in the ambulatory setting in the past, discharging patients,
especially pediatric patients, with a prescription for a codeine product for postoperative pain …