Pain affects approximately 100 million Americans. Pain harms quality of life and costs
patients billions of dollars per year. Clinically, nonpharmacologic and pharmacologic …

Easing physical distress is a major focus in the practice of palliative care in a child with
malignancy throughout the disease course from diagnosis to cure and survivorship or death …

Background Polymorphisms in the opioid receptor genes may affect the pharmacodynamics
(PD) of oxycodone and be part of the reason behind the diversity in clinical response. The …

Morphine is an essential medication for treatment of severe acute and chronic pain.
However, interindividual differences in pain sensitivity and analgesic response make the …

There is substantial variability in patients' response to medications. The healthcare system is
in the midst of a transformation to a targeted precision health approach in which disease …

One of the most difficult parts in forensic toxicology is to interpret obtained drug
concentrations. Was it therapeutic, toxic or even lethal to the particular individual that the …

The isolation of morphine by Friedrich Serturner in 1804 unlocked the powerful essence of
opium. There are now a plethora of natural, synthetic, and semi-synthetic opioid analgesics …

The current concept of personalized medicine looks to provide “the right patient with the right
drug at the right dose at the right time,” by tailoring medical treatment to unique personal …

Purpose: Topical analgesics have gained acceptance in guidelines for the treatment of pain.
The Kailo Pain Patch® is a topically applied analgesic adhesive patch, with a recent study …

Enhanced Recovery After Surgery (ERAS) is an innovative approach in surgical specialties
that aims to reduce postoperative complications, length of hospital stay and healthcare costs …