Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …

Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …

Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Context Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor
growth and metastases in animal models. However, the influence of aspirin on survival after …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …