Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line
FE Bennani, L Doudach, Y Cherrah, Y Ramli… - Bioorganic …, 2020 - Elsevier
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
Recent advances in bioactive pyrazoles
ŞG Küçükgüzel, S Şenkardeş - European Journal of Medicinal Chemistry, 2015 - Elsevier
Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …
have been investigated in the development of novel compounds with hypoglycemic …
Cancer and inflammation: an old intuition with rapidly evolving new concepts
G Trinchieri - Annual review of immunology, 2012 - annualreviews.org
Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …
molecular and cellular pathways involved in the connection between cancer and …
Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …
Aspirin use and survival after diagnosis of colorectal cancer
Context Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor
growth and metastases in animal models. However, the influence of aspirin on survival after …
growth and metastases in animal models. However, the influence of aspirin on survival after …
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
RA Gupta, RN DuBois - Nature Reviews Cancer, 2001 - nature.com
Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
Cyclooxygenase-2: a therapeutic target
ME Turini, RN DuBois - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
K Subbaramaiah, AJ Dannenberg - Trends in pharmacological sciences, 2003 - cell.com
Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …
COX-2: a molecular target for colorectal cancer prevention
JR Brown, RN DuBois - Journal of Clinical Oncology, 2005 - ascopubs.org
Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …
considerable attention due to its role in human cancers. Observational and randomized …
Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer
AJ Dannenberg, NK Altorki, JO Boyle, C Dang… - The lancet …, 2001 - thelancet.com
Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …
necessary for the development of therapeutic strategies to prevent cancer …