[HTML][HTML] Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis

Y Tong, X Li, Q Deng, J Shi, Y Feng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the
pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related …

Naringenin as a natural immunomodulator against T cell-mediated autoimmune diseases: literature review and network-based pharmacology study

Z Liu, X Niu, J Wang - Critical reviews in food science and nutrition, 2023 - Taylor & Francis
Abstract T cells, especially CD4+ T helper (Th) cells, play a vital role in the pathogenesis of
specific autoimmune diseases. Naringenin, a citrus flavonoid, exhibits anti-inflammatory, anti …

Based on network pharmacology and in vitro experiments to prove the effective inhibition of myocardial fibrosis by Buyang Huanwu decoction

T Wang, X Jiang, Y Ruan, J Zhuang, Y Yin - Bioengineered, 2022 - Taylor & Francis
Among cardiovascular diseases, myocardial fibrosis (MF) is a major pathological change
underlying heart failure and is associated with a high mortality rate. However, the molecular …

[HTML][HTML] Methamphetamine disturbs gut homeostasis and reshapes serum metabolome, inducing neurotoxicity and abnormal behaviors in mice

KK Zhang, LJ Chen, JH Li, JL Liu, LB Wang… - Frontiers in …, 2022 - frontiersin.org
As an illicit psychostimulant, repeated methamphetamine (MA) exposure results in addiction
and causes severe neurotoxicity. Studies have revealed complex interactions among gut …

[HTML][HTML] Diagnostic gene signatures and aberrant pathway activation based on m6A methylation regulators in rheumatoid arthritis

Q Geng, X Cao, D Fan, X Gu, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease (AD) characterized by
persistent synovial inflammation, bone erosion and progressive joint destruction. This …

[HTML][HTML] The development of naringin for use against bone and cartilage disorders

J Gan, X Deng, Y Le, J Lai, X Liao - Molecules, 2023 - mdpi.com
Bone and cartilage disorders are the leading causes of musculoskeletal disability. There is
no absolute cure for all bone and cartilage disorders. The exploration of natural compounds …

[HTML][HTML] Phytochemical and medicinal profiling of Russula vinosa Lindbl (RVL) using multiomics techniques

H Chen, H Zhou, Z She, H Lu, M Wen, X Wang, Z Wei… - LWT, 2024 - Elsevier
Russula vinosa Lindbl (RVL) is a multifunctional edible fungus that has recently gained
widespread attention due to its numerous nutritious, delicious, and medicinal properties …

[HTML][HTML] Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review

Ł Pulik, P Łęgosz, G Motyl - Reumatologia, 2023 - ncbi.nlm.nih.gov
Although the pathological mechanisms involved in osteoarthritis (OA) and rheumatoid
arthritis (RA) are different, the onset and progression of both diseases are associated with …

Transcriptome and proteomics conjoint analysis reveal metastasis inhibitory effect of 6-shogaol as ferroptosis activator through the PI3K/AKT pathway in human …

RH Ma, ZJ Ni, K Thakur, CL Cespedes-Acuña… - Food and Chemical …, 2022 - Elsevier
Endometrial cancer remains as one of the widespread female malignancies despite the
existing treatment measures mainly surgery, radiotherapy, and chemotherapy. In recent …

[HTML][HTML] Exploration of the molecular basis of forsythia fruit in the prevention and treatment of cholestatic liver injury through network pharmacology and molecular …

K Fu, Y Li, S Dai, Y Li - Nutrients, 2023 - mdpi.com
Forsythia fruit, edible fruit of Forsythia suspensa (Thunb.) Vahl, which has been found to be
effective in treating cholestasis. However, its key component for alleviating cholestasis has …