Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …

Objective To develop evidence-based European Alliance of Associations for Rheumatology
(EULAR) points to consider (PtCs) for the management of difficult-to-treat rheumatoid …

Many patients with inflammatory bowel disease (IBD) have persistent symptoms and
disease activity despite the best available medical or surgical treatments. These patients are …

Objectives To summarise, by a systematic literature review (SLR), the evidence regarding
pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat …

The European Alliance of Associations for Rheumatology recently defined difficult to treat
(D2T) rheumatoid arthritis (RA) and provided points to consider in its management. This …

Pain is a significant issue in Rheumatoid Arthritis (RA) and can have a negative impact on
patients' quality of life. Despite optimal control of inflammatory disease, residual chronic pain …

Objectives Patients with difficult-to-treat rheumatoid arthritis (RA) remain symptomatic
despite treatment according to current European League Against Rheumatism (EULAR) …

Management of RA patients has significantly improved over the past decades. However, a
substantial proportion of patients is difficult-to-treat (D2T), remaining symptomatic after …

Over the past several decades, the treatment of rheumatoid arthritis (RA) has advanced
significantly, and clinical, structural, and functional remission are achievable therapeutic …