Although the management of rheumatoid arthritis (RA) has improved remarkably with new
pharmacological therapies, there is still a significant part of patients not reaching treatment …

Objectives To demonstrate that unsuccessful treatment optimization in early disease is
associated with difficult-to-treat RA (D2T-RA). Methods In this retrospective multicentre …

Objective To investigate the prevalence of poly-refractory rheumatoid arthritis (RA) defined
as failure of all biological (b)/targeted synthetic (ts)-disease-modifying drugs (DMARDs). To …

In recent years, difficult-to-treat rheumatoid arthritis (D2T RA) has attracted significant
attention from rheumatologists due to its poor treatment response and the persistent …

Difficult-to-treat rheumatoid arthritis is a heterogeneous term in which patients may present
with difficulties in their management for different reasons. This can ultimately lead to patients …

Despite the improvement in treatment for people with RA,∼ 30% of patients remain
symptomatic in the presence of optimized medical therapy, described as having 'difficult-to …

Objectives To determine the impact of difficult-to-treat rheumatoid arthritis (D2T RA) on
(costs related to) healthcare utilization, other resource use and work productivity. Methods …

Rheumatoid arthritis (RA) is a chronic, autoimmune and systemic inflammatory disease
affecting 1% of the population worldwide. Immune suppression of the activity and progress …

Background The new concept of difficult-to-treat rheumatoid arthritis (D2T RA) refers to RA
patients who remain symptomatic after several lines of treatment, resulting in a high patient …

Purpose of Review A subset of patients with rheumatoid arthritis (RA) who fail multiple
biologic therapies are deemed to have “difficult-to-treat”(D2T) RA. In 2021, a European …