Objective Acute central nervous system (CNS) injury after stroke and trauma remains a
clinical challenge with limited diagnostic and therapeutic approaches. In this article, we …

Cerebral ischemia and its consequences like transient ischemic attack, aneurysm and stroke
are the common and devastating conditions which remain the leading cause of mortality …

Mitochondrial diseases (MDs) are inherited genetic conditions characterized by pathogenic
mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Current therapies are still …

Mitochondria generate ATP essential for neuronal growth, function, and regeneration. Due
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …

The mitochondrial theory of aging is characterized by mitochondrial electron transport chain
dysfunction. As a hallmark of aging, an increasing number of investigations have attempted …

Background In lung transplantation, ischemia-reperfusion injury associated with
mitochondrial damage can lead to graft rejection. Intact, exogenous mitochondria provide a …

Ischemic stroke is one of the major causes of morbidity and mortality worldwide.
Mitochondria play a vital role in the pathological processes of cerebral ischemic injury, but …

Mitochondrial cardiomyopathy (MCM) is characterized by abnormal heart-muscle structure
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …

As the major energy supplier in cells, mitochondria play a significant role in regulating
cellular processes. The pathogenesis of various diseases is found to be associated with …

Mitochondria have been primarily considered intracellular organelles that are responsible
for generating energy for cell survival. However, accumulating evidence suggests that …