New biological tools provide new techniques to probe fundamental biological processes.
Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …

Protein–protein interactions (PPIs) are vital to all biological processes. These interactions
are often dynamic, sometimes transient, typically occur over large topographically shallow …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

The development of inhibitors that selectively block protein–protein interactions (PPIs) is
crucial for chemical biology, medicinal chemistry, and biomedical sciences. Herein, we …

Hypoxia‐inducible factors (HIFs) are transcription factors that activate the transcription of
genes necessary to circumvent to hypoxic (low oxygen level) environments. In …

Metabolic reprogramming of host cells is key to the foundation of a successful viral infection.
Hypoxia inducible factors (HIFs) mediate oxygen utilization by regulating cellular …

Hypoxia inducible factor (HIF) is a heterodimeric transcription factor composed of an oxygen-
regulated α subunit and a constitutively expressed β subunit that serves as the master …