[HTML][HTML] Evaluation of biological activity of natural compounds: current trends and methods
C Barba-Ostria, SE Carrera-Pacheco… - Molecules, 2022 - mdpi.com
Natural compounds have diverse structures and are present in different forms of life.
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …
[HTML][HTML] The central role of thrombin in bleeding disorders
C Negrier, M Shima, M Hoffman - Blood reviews, 2019 - Elsevier
Maintaining normal hemostasis relies on a regulated system of procoagulant and
anticoagulant pathways, and disruption of these processes leads to the loss of hemostatic …
anticoagulant pathways, and disruption of these processes leads to the loss of hemostatic …
[HTML][HTML] Thrombin generation assays for global evaluation of the hemostatic system: perspectives and limitations
The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive
enough to detect hypercoagulable and mild hypocoagulable states. Under different …
enough to detect hypercoagulable and mild hypocoagulable states. Under different …
The effect of the direct factor Xa inhibitors apixaban and rivaroxaban on haemostasis tests: a comprehensive assessment using in vitro and ex vivo samples
R Bonar, EJ Favaloro, S Mohammed, M Ahuja… - Pathology, 2016 - Elsevier
The direct oral anticoagulants (DOACs), now including dabigatran, apixaban and
rivaroxaban, have given clinicians alternative options to low molecular weight heparins …
rivaroxaban, have given clinicians alternative options to low molecular weight heparins …
In vitro thrombogenicity testing of biomaterials
S Braune, RA Latour, M Reinthaler… - Advanced …, 2019 - Wiley Online Library
The short‐and long‐term thrombogenicity of implant materials is still unpredictable, which is
a significant challenge for the treatment of cardiovascular diseases. A knowledge‐based …
a significant challenge for the treatment of cardiovascular diseases. A knowledge‐based …
[HTML][HTML] “In less than no time”: feasibility of rotational thromboelastometry to detect anticoagulant drugs activity and to guide reversal therapy
V Pavoni, L Gianesello, D Conti, P Ballo… - Journal of Clinical …, 2022 - mdpi.com
Anticoagulant drugs (ie, unfractionated heparin, low-molecular-weight heparins, vitamin K
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …
Effect of tannic acid on blood components and functions
L Deng, Y Qi, Z Liu, Y Xi, W Xue - Colloids and Surfaces B: Biointerfaces, 2019 - Elsevier
Tannic acid (TA) has become increasingly important as a biomaterial because of its ability to
capture free radicals and form complexes with metal ions. Nevertheless, a systematic …
capture free radicals and form complexes with metal ions. Nevertheless, a systematic …
Impact of gene polymorphisms in drug‐metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation
J Nakagawa, T Kinjo, M Iizuka, K Ueno… - Basic & Clinical …, 2021 - Wiley Online Library
Rivaroxaban is excreted from the body via multiple pathways involving glomerular filtration,
drug‐metabolizing enzymes and transporters. In this study, we aimed to examine the impact …
drug‐metabolizing enzymes and transporters. In this study, we aimed to examine the impact …
Role of thromboelastography and rotational thromboelastometry in the management of cardiovascular diseases
B Korpallová, M Samoš, T Bolek… - Clinical and Applied …, 2018 - journals.sagepub.com
The monitoring of coagulation by viscoelastometric methods—thromboelastography and
rotational thromboelastometry—may detect the contributions of cellular and plasma …
rotational thromboelastometry—may detect the contributions of cellular and plasma …
Use of DOAC Stop for elimination of anticoagulants in the thrombin generation assay
WF Kopatz, HJM Brinkman, JCM Meijers - Thrombosis research, 2018 - Elsevier
Calibrated automated thrombography (CAT) is useful in monitoring the anticoagulant status
of patients treated with direct oral anticoagulants (DOACs). This as well as other applications …
of patients treated with direct oral anticoagulants (DOACs). This as well as other applications …