The MHC-self immunopeptidome of professional antigen presenting cells is a cognate
ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T …

Follicular regulatory T (Tfr) cells play various roles in immune responses, contributing to both
positive and negative regulation of foreign antigen-specific B cell responses, control over …

Objective To evaluate NKTR-358, a polyethylene glycol-interleukin-2 conjugate composition
designed to selectively induce regulatory T cells (Tregs), in first-in-human studies. Methods …

Hypoxia‐induced pulmonary hypertension (HPH) is a progressive and lethal disease
characterized by the uncontrolled proliferation of pulmonary artery smooth muscle cells …

Introduction Defective interleukin-2 (IL-2) production contributes to immune system
imbalance in patients with systemic erythematosus lupus (SLE). Recent clinical studies …

Follicular regulatory T (Tfr) cells are a novel and unique subset of effector regulatory T (Treg)
cells that are located in germinal centers (GCs). Tfr cells express transcription profiles that …

Problem The phenotypes and functions of B and CD4+ T‐helper cell subsets during chronic
inflammation of the endometria remain largely unexplored. This study aimed to investigate …

Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a
specialized subset of T cells called “T follicular helper”(TFH) cells that help select Ag-specific …

Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathogenesis is
typically related to B cell hyperactivity. However, parallelly, the breaking of immune …

Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by
thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic …