[HTML][HTML] Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

IM Bouligny, KR Maher, S Grant - Blood reviews, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches

N Tosic, I Marjanovic, J Lazic - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …

[HTML][HTML] Acute myeloid leukemia in children: emerging paradigms in genetics and new approaches to therapy

SE Conneely, AM Stevens - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Acute myeloid leukemia (AML) in children remains a
challenging disease to cure with suboptimal outcomes particularly when compared to the …

[HTML][HTML] New therapeutic strategies for adult acute myeloid leukemia

H Ishii, S Yano - Cancers, 2022 - mdpi.com
Simple Summary For almost 40 years, the combination of anthracyclines and cytarabine,
called 3+ 7, has been the standard of induction chemotherapy for the treatment of acute …

The core concepts of core binding factor acute myeloid leukemia: current considerations for prognosis and treatment

C Darwish, K Farina, D Tremblay - Blood Reviews, 2023 - Elsevier
Core binding factor acute myeloid leukemia (CBF AML), defined by t (8; 21) or inv (16), is a
subset of favorable risk AML. Despite its association with a high complete remission rate …

[HTML][HTML] Allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia in first complete remission: a meta-analysis

R Masetti, E Muratore, D Gori, A Prete, F Locatelli - Annals of Hematology, 2022 - Springer
Identification of pediatric patients with acute myeloid leukemia (AML) candidates to receive
allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission …

Children's Oncology Group's 2023 blueprint for research: Myeloid neoplasms

TM Cooper, TA Alonzo, SK Tasian… - Pediatric Blood & …, 2023 - Wiley Online Library
During the past decade, the outcomes of pediatric patients with acute myeloid leukemia
(AML) have plateaued with 5‐year event‐free survival (EFS) and overall survival (OS) of …

[HTML][HTML] Mutated KIT tyrosine kinase as a novel molecular target in acute myeloid leukemia

S Katagiri, SG Chi, Y Minami, K Fukushima… - International Journal of …, 2022 - mdpi.com
KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells.
Since KIT is activated by overexpression or mutation and plays an important role in the …

Treatment of acute myeloid leukemia in children: A practical perspective

G Egan, Y Chopra, S Mourad… - Pediatric Blood & …, 2021 - Wiley Online Library
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease that requires a
multifaceted treatment approach. Although outcomes for low‐risk AML have improved …

The genomics of acute myeloid leukemia in children

SE Conneely, RE Rau - Cancer and Metastasis Reviews, 2020 - Springer
Acute myeloid leukemia (AML) is a clinically, morphologically, and genetically
heterogeneous disorder. Like many malignancies, the genomic landscape of pediatric AML …