Toward identifying key mechanisms of progression in multiple sclerosis
L Husseini, A Geladaris, MS Weber - Trends in Neurosciences, 2023 - cell.com
A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …
accumulation of disability over an often decades-long disease course. Disability progression …
Granzymes in health and diseases: the good, the bad and the ugly
L Cigalotto, D Martinvalet - Frontiers in Immunology, 2024 - frontiersin.org
Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M
and K. They were first discovered in the 1980s within cytotoxic granules released during NK …
and K. They were first discovered in the 1980s within cytotoxic granules released during NK …
[HTML][HTML] Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis
S Yang, Y Sun, M Long, X Zhou, M Yuan… - Particle and Fibre …, 2023 - Springer
Chronic exposure to silica can lead to silicosis, one of the most serious occupational lung
diseases worldwide, for which there is a lack of effective therapeutic drugs and tools …
diseases worldwide, for which there is a lack of effective therapeutic drugs and tools …
Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …
Characterizing CD8+ TEMRA Cells in CP/CPPS Patients: Insights from Targeted Single-Cell Transcriptomic and Functional Investigations
Background The specific involvement of the CD8+ T effector memory RA (TEMRA) subset in
patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has largely not …
patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has largely not …
[HTML][HTML] Case report: Granzyme-B expression by T-and B-cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous …
VO Boldrini, MR Brito, RPS Quintiliano… - Frontiers in …, 2023 - frontiersin.org
Background The expression of serine protease granzyme-B (GzmB) by circulating CD8+ T
lymphocytes has been recently suggested as a biomarker for poor immunotherapy response …
lymphocytes has been recently suggested as a biomarker for poor immunotherapy response …
Mechanism of indolepropionic acid mediating allergic rhinitis by regulating AKT/T-bet/GZMB/TTP/IL-10 axis
L Gao, Y Song, J Zhang, Y Zhao, H Hu, Y Feng - 2024 - researchsquare.com
Objective: Allergic rhinitis (AR) is one of the most common chronic diseases in the world,
which often brings confusion to countless patients. The purpose of this study was to explore …
which often brings confusion to countless patients. The purpose of this study was to explore …
Investigating the Ability of Plasma Proteomics in Diagnosing and Monitoring Multiple Sclerosis
X Wang, Z Zhao, Z Shi, H Chen, H Zhou - Available at SSRN 4727780 - papers.ssrn.com
Background: Sensitive protein biomarkers are important for the early diagnosis and
monitoring of multiple sclerosis (MS) progression, augmenting treatment efficacy and …
monitoring of multiple sclerosis (MS) progression, augmenting treatment efficacy and …