Recent studies implicate channels of the transient receptor potential vanilloid family (eg,
TRPV1) in regulating vascular tone; however, little is known about these channels in the …

Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following
myocardial infarction (MI), but the critical neural pathways involved are not well understood …

Refractory angina (RFA) is a debilitating disease characterized by cardiac pain resistant to
conventional treatments for coronary artery disease including nitrates, calcium-channel and …

The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca2+-
permeable nonspecific cation channel activated by various painful stimuli including …

The cannabinoids comprise three major classes of substances, including compounds
derived from the cannabis plant (eg Δ9‐tetrahydrocannabinol and the chemically related …

Background—Chest pain is a hallmark of myocardial ischemia, but its underlying signaling
mechanisms remain poorly understood. The capsaicin receptor, vanilloid receptor-1 (VR1) …

Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …

Angina pectoris is cardiac pain that typically is manifested as referred pain to the chest and
upper left arm. Atypical pain to describe localization of the perception, generally …

In this review we examine the exercise pressor reflex in health and disease. The role of
metabolic and mechanical stimulation of thin fiber muscle afferents is discussed. The role …

Persistent excessive sympathetic activation greatly contributes to the pathogenesis of
chronic heart failure (CHF) and hypertension. Cardiac sympathetic afferent reflex (CSAR) is …