Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links
between inflammatory signals and pain-mediating neuronal signals is essential for …

The endocannabinoid anandamide and cannabinoid (CB) receptors have been implicated
in the hypotension in various forms of shock and in advanced liver cirrhosis. Anandamide …

A humoral mechanism of cardioprotection by remote ischemic preconditioning (RIP) has
been clearly demonstrated in various models of ischemia–reperfusion including upper and …

OBJECTIVE: This study evaluated serum levels of the neuropeptides calcitonin gene-related
peptide (CGRP) and substance P (SP) in coronary artery disease (CAD) patients with and …

Exercise intolerance is a hallmark symptom of cardiovascular disease and likely occurs via
enhanced activation of muscle metaboreflex-induced vasoconstriction of the heart and …

Rationale: Acid-sensing ion channels (ASICs) are Na+ channels that are activated by acidic
pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes …

The transient receptor potential vanilloid type 1 ion channel (TRPV1) was identified as a
receptor responsible for mediating the intense burning sensation following exposure to heat …

Excessive sympathetic activity contributes to the pathogenesis of hypertension and the
progression of the related organ damage. Adipose afferent reflex (AAR) is a sympatho …

The present inventions relate, in part, to the discovery that administration of TRPV1 agonist
under conditions in which a significant amount of agonist is rapidly and efficiently deliv ered …

We have shown that the gene SCN10A encoding the sodium channel Nav1. 8 is a
susceptibility factor for heart block and serious ventricular arrhythmia. Since Nav1. 8 is …