Imbalances in the opposing actions of sympathetic and parasympathetic nerves controlling
the heart enhance risk for arrhythmia and sudden cardiac death after myocardial infarction …

Background: The autonomic nervous system response to apnea and its mechanistic
connection to atrial fibrillation (AF) are unclear. We hypothesize that sensory neurons within …

Research on vanilloid receptor-1 (VR1/TRPV1) has expanded rapidly in the past few years
as evidence supporting the potential for this new mechanism to offer a way to treat a wide …

Cardiac sympathetic afferent reflex (CSAR) is involved in sympathetic activation. The
present study was designed to investigate the contribution of enhanced CSAR to …

Hypertension is associated with increased sympathetic activity. A component of this
sympathoexcitation may be driven by increased signaling from sensory endings from the …

BACKGROUND: Evidence indicated an involvement of afferent nerves in the pathology of
acute myocardial infarction. This study was undertaken to clarify the role and mechanisms …

Background: A myocardial ischemia/reperfusion (IR) injury activates the transient receptor
potential vanilloid 1 (TRPV1) dorsal root ganglion (DRG) neurons. The activation of TRPV1 …

Sleep apnea is highly associated with atrial fibrillation (AF), and both diseases are highly
prevalent in the United States. The mechanistic underpinnings that contribute to their …

Muscle metabolic by-products stimulate thin fiber muscle afferent nerves and evoke reflex
increases in blood pressure and sympathetic nerve activity. Previous studies reported that …

The treatment of hypertension and heart failure remains a major challenge to healthcare
providers. Despite therapeutic advances, heart failure affects more than 26 million people …