Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation
Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic
inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or …
inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or …
[HTML][HTML] Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model
Z Pei, Y Qin, X Fu, F Yang, F Huo, X Liang, S Wang… - Redox biology, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …
[HTML][HTML] Disease-associated metabolic pathways affected by heavy metals and metalloid
Increased exposure to environmental heavy metals and metalloids and their associated
toxicities has become a major threat to human health. Hence, the association of these …
toxicities has become a major threat to human health. Hence, the association of these …
[HTML][HTML] The role of iron homeostasis and iron-mediated ROS in cancer
JF Ying, ZB Lu, LQ Fu, Y Tong, Z Wang… - American journal of …, 2021 - ncbi.nlm.nih.gov
As an important trace element, iron plays an essential role in many biology processes like
cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron …
cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron …
[HTML][HTML] Emerging mechanisms and targeted therapy of ferroptosis in neurological diseases and neuro-oncology
Y Wang, B Tang, J Zhu, J Yu, J Hui… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation
that involves a variety of biological processes, such as iron metabolism, lipid metabolism …
that involves a variety of biological processes, such as iron metabolism, lipid metabolism …
[HTML][HTML] Iron metabolism in the tumor microenvironment—Implications for anti-cancer immune response
New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …
[HTML][HTML] A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma
In this study, we analyzed the clinical significance of ferroptosis-related genes (FRGs) in 32
cancer types in the GSCA database. We detected a 2-82% mutation rate among 36 FRGs. In …
cancer types in the GSCA database. We detected a 2-82% mutation rate among 36 FRGs. In …
[HTML][HTML] Iron: an essential element of cancer metabolism
MY Hsu, E Mina, A Roetto, PE Porporato - Cells, 2020 - mdpi.com
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …
a hostile environment characterized by nutrient deprivation, poor vascularization and …
[HTML][HTML] The potential role of vitamin C in empowering cancer immunotherapy
T Bedhiafi, VP Inchakalody, Q Fernandes… - Biomedicine & …, 2022 - Elsevier
Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and
vegetables and widely known for its potent antioxidant activity. Several studies have …
vegetables and widely known for its potent antioxidant activity. Several studies have …