Progesterone action in breast, uterine, and ovarian cancers

CH Diep, AR Daniel, LJ Mauro… - Journal of …, 2015 - jme.bioscientifica.com
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …

The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways

CL Mellor, FP Steinmetz… - Critical reviews in …, 2016 - Taylor & Francis
The development of adverse outcome pathways (AOPs) is becoming a key component of
twenty-first century toxicology. AOPs provide a conceptual framework that links the …

Control of oocyte release by progesterone receptor-regulated gene expression

RL Robker, LK Akison… - Nuclear receptor …, 2009 - journals.sagepub.com
The progesterone receptor (PGR) is a nuclear receptor transcription factor that is essential
for female fertility, in part due to its control of oocyte release from the ovary, or ovulation. In …

[图书][B] Combined estrogen-progestogen contraceptives and combined estrogen-progestogen menopausal therapy

IARC Working Group on the Evaluation of … - 2007 - books.google.com
This ninety-first volume of IARC Monographscontains evaluations of the carcinogenic
hazard to humans of combined estrogen-progestogen contraceptives and combined …

StackPR is a new computational approach for large-scale identification of progesterone receptor antagonists using the stacking strategy

N Schaduangrat, N Anuwongcharoen, MA Moni… - Scientific Reports, 2022 - nature.com
Progesterone receptors (PRs) are implicated in various cancers since their
presence/absence can determine clinical outcomes. The overstimulation of progesterone …

DNA damage responses in mammalian oocytes

JK Collins, KT Jones - Reproduction, 2016 - rep.bioscientifica.com
Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …

Sex steroid receptors in immune cells

S Kovats, E Carreras, H Agrawal - Sex hormones and immunity to infection, 2009 - Springer
Lymphocytes and myeloid cells express estrogen, progesterone, and androgen receptors,
and studies show that sex steroid hormones directly modulate their activation, lifespan, and …

Progesterone antagonist and selective progesterone modulator in the treatment of excessive uterine bleeding

BCJM Fauser, E Loumaye - US Patent 8,569,274, 2013 - Google Patents
Progesterone antagonists and SPRM are useful to prepare a medication for the treatment or
the prophylaxis of excessive uterine bleeding in women with spontaneous or iatrogenic …

[HTML][HTML] Antiprogestins in gynecological diseases

AA Goyeneche, CM Telleria - Reproduction (Cambridge, England), 2015 - ncbi.nlm.nih.gov
Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …

Health-related quality of life with ulipristal acetate for treatment of uterine leiomyomas: a randomized controlled trial

AS Lukes, D Soper, A Harrington… - Obstetrics & …, 2019 - journals.lww.com
OBJECTIVE: To investigate effects of ulipristal acetate on health-related quality of life (QOL)
and symptom severity in women with symptomatic uterine leiomyomas and abnormal uterine …