Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

The posttranslational addition of ubiquitin (Ub) helps control the half-life, localization, and
action of many intracellular plant proteins. A primary function is the degradation of …

Background The covalent attachment of ubiquitin to a substrate protein changes its fate.
Notably, proteins typically tagged with a lysine48-linked polyubiquitin chain become …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …

COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and
physiological functions are only beginning to be understood. It is conserved throughout …

Human exposures to environmental toxicants have been associated with etiology of many
diseases including inflammation, cancer, and cardiovascular and neurodegenerative …

Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin
ligases. CRLs regulate an extensive number of dynamic cellular processes, including …

The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating
numerous protein substrates. Cand1, a 120 kDa HEAT repeat protein, forms a tight complex …