Objective: The authors investigated the clinical outcomes of commonly used antidepressants
among older adults who initiated first-time antidepressants for depression by analyzing the 1 …

Background The choice of antidepressants for initial pharmacological treatment of
depression in older adults and associated patients' characteristics are understudied. We …

Depressive disorders are disabling conditions that account for high social costs. Pilates
demonstrated to have several beneficial effects on health. Objective of this manuscript was …

Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and
glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric …

Background Serotonin-norepinephrine reuptake inhibitors (SNRIs) are among the most
frequently prescribed antidepressants (ADs) for major depressive disorder (MDD), with an …

GW117, a novel derivate compound of agomelatine that acts as both a 5-HT2C receptor
antagonist and a MT1/MT2 receptor agonist, likely underlines the potent antidepressant …

Background Impulsivity is a transdiagnostic feature linked to severe clinical expression and
a potential target for psychopharmacological strategies. Biological underpinnings are largely …

Objective To investigate the comparative effectiveness of commonly used selective
serotonin reuptake inhibitors (SSRIs) for comorbid depression in older adults with chronic …

Since selective serotonin reuptake inhibitors, that are recommended as first-line
antidepressant psychopharmacotherapy for major depressive disorder (MDD), may not be …

The clinical phenotype of the so-called late-onset depression (LOD) affecting up to 30% of
older adults and yielding heterogeneous manifestations concerning symptoms, severity and …