As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

Background The dry root and rhizome of Salvia miltiorrhiza Bunge, or Danshen, is a well-
known traditional Chinese medicine with anticoagulant activity. Taking into account that …

Abstract Ethnopharmacological relevance Dang-Gui-Si-Ni (DGSN) decoction is a classic
prescription in the clinical practice of traditional Chinese Medicine (TCM). DGSN decoction …

Direct oral anticoagulants are an important and relatively new class of synthetic
anticoagulant drugs commonly used for the pharmacotherapy of thromboembolic disorders …

Enzymes involved in the coagulation process have received great attention as potential
targets for the development of oral anti-coagulants. Among these enzymes, coagulation …

Direct inhibition of FXa has emerged as an effective strategy to achieve anticoagulation
maintaining normal hemostasis with minimal bleeding risks. A novel series of …

The structures of the mono-and the dihalogenated N-unsubstituted 2-aminobenzamides
were characterized by means of the spectroscopic (1H-NMR, UV-Vis, FT-IR, and FT-Raman) …

Background: Despite the introduction of direct oral anticoagulants, the search for new oral
anticoagulants remains an urgent task. Objective: By using docking and scoring, based on …

Rivaroxaban (RIV) is a direct oral anticoagulant (DOAC) targeting activated coagulation
factor X (FXa). An earlier study reported the F174A mutant of FXa resistant to a RIV‐like …

The review discusses main approaches to searching for new low-molecular-weight
inhibitors of coagulation factors IIa, Xa, IXa, and XIa and the results of such studies …