Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming
counter attack of TB worldwide. However, when it was known that TB can be cured …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

Rapid advances in DNA sequencing technology (“next-generation sequencing”) have
inspired optimism about the potential of human genomics for “precision medicine.” …

Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …

Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …

Background Repeated culture reduces within-sample Mycobacterium tuberculosis genetic
diversity due to selection of clones suited to growth in culture and/or random loss of …

Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …

With the reduction in sequencing price and acceleration of sequencing speed, it is
particularly important to directly link the genotype and phenotype of bacteria. Here, we firstly …

Background Despite the obvious advantages of metagenomic next-generation sequencing
(mNGS) in etiological diagnosis of various infectious diseases, there are few reports on …