In recent years much attention has been focused on the functional importance of 5-HT#, 5-
HT $ and 5-HT% receptors in the pathogenesis of neuropsychiatric and other diseases. In …

hydroxytryptamine (5-HT, serotonin) is a major neurotransmitter involved in the modulation
of behavior and the manifestation of various psychiatric disorders, and is a pharmacological …

Despite the human 5-HT 5A receptor being cloned in 1994, the biological function of this
receptor has not been extensively characterized due to a lack of specific ligands. We …

High-throughput screening of an array of biphenylmethylamines synthesised by high-
throughput solid-phase chemistry resulted in the identification of compounds with high …

The present study examined the roles of ventrolateral orbital cortex (VLO) 5-HT 1, 5-HT 2, 5-
HT 3, 5-HT 4, 5-HT 5, 5-HT 6 and 5-HT 7 receptor subtypes in mediating 5-HT-induced …

Endogenous serotonin and serotonergic drugs influence many aspects of circadian rhythms,
including phase shifts, onset of locomotor activity, and period length and integrity of rhythms …

Screening of various agents resulted in the identification of 5-methyl-1, 2, 3, 4-tetrahydro-γ-
carboline (1; Ki= 5,300 nM) as a compound with modest affinity for mouse 5-HT5A receptors …

Cerebellar outputs from the deep cerebellar nuclei (DCN) are critical for generating and
controlling movement. DCN neuronal activity is primarily controlled by GABAergic inhibitory …

It is known that serotonin exerts its different nociceptive and motor functions by interacting
with distinct receptors subtypes, which could be either G-protein coupled or ionotropic …

Although the 5-HT5 receptor subfamily was discovered more than 15 years ago, it is
unambiguously the least known 5-HT receptor subtype. The Gi/G0-mediated signal …