Aims Ketamine remains an important medicine in both specialist anaesthesia and aspects of
pain management. At the same time, its use as a recreational drug has spread in many parts …

Ketamine was discovered in the 1960s and released for public use in 1970. Originally
developed as a safer alternative to phencyclidine, ketamine is primarily used in clinical …

OBJECTIVES: Ketamine hydrochloride is an N-methyl-d-aspartic acid receptor antagonist
used as an anesthetic agent in human and veterinary procedures. Increasingly, it is being …

Ketamine is a dissociative anesthetic and substance of abuse. Numerous effects can result
from the abuse of ketamine. Death from acute direct toxicity is rare. Ketamine can alter …

Existing treatments for major depressive disorder (MDD) usually take weeks to months to
achieve their antidepressant effects, and a significant number of patients do not have …

Abstract Study Type-Symptom prevalence (prospective cohort) Level of Evidence 1b What's
known on the subject? and What does the study add? Case series have described lower …

Introduction Ketamine is a pharmaceutical drug possessing both analgesic and anaesthetic
properties. As an anaesthetic, it induces anaesthesia by producing analgesia with a state of …

The real or perceived proximity to death often results in a non-ordinary state of
consciousness characterized by phenomenological features such as the perception of …

Background Polydrug use may challenge effective treatment for substance use disorders.
We evaluate whether secondary substance use modifies the association between treatment …

In 2016 the Psychoactive Substances Bill banned trading but not possession of all current
and future novel psychoactive substances (NPS), sometimes incorrectly called “legal highs,” …