The physiology, signaling, and pharmacology of dopamine receptors

JM Beaulieu, RR Gainetdinov - Pharmacological reviews, 2011 - ASPET
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

Dopamine targeting drugs for the treatment of schizophrenia: past, present and future

P Li, GL Snyder, KE Vanover - Current topics in medicinal …, 2016 - ingentaconnect.com
Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

S Miyamoto, N Miyake, LF Jarskog… - Molecular …, 2012 - nature.com
Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II

SF Zhou - Clinical pharmacokinetics, 2009 - Springer
Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Effects of prenatal infection on brain development and behavior: a review of findings from animal models

P Boksa - Brain, behavior, and immunity, 2010 - Elsevier
Epidemiological studies with human populations indicate associations between maternal
infection during pregnancy and increased risk in offspring for central nervous system (CNS) …

General anesthesia and altered states of arousal: a systems neuroscience analysis

EN Brown, PL Purdon… - Annual review of …, 2011 - annualreviews.org
Placing a patient in a state of general anesthesia is crucial for safely and humanely
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …

Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology

TRE Barnes… - Journal of …, 2011 - journals.sagepub.com
These guidelines from the British Association for Psychopharmacology address the scope
and targets of pharmacological treatment for schizophrenia. A consensus meeting, involving …

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development

RP Juster, G Bizik, M Picard… - Development and …, 2011 - cambridge.org
The allostatic load (AL) model represents an interdisciplinary approach to comprehensively
conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle …

Antipsychotic drugs: from receptor-binding profiles to metabolic side effects

S Siafis, D Tzachanis, M Samara… - Current …, 2018 - ingentaconnect.com
Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …

Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by “resting state” functional magnetic resonance …

S Lui, T Li, W Deng, L Jiang, Q Wu… - Archives of general …, 2010 - jamanetwork.com
Context Most of what we know about antipsychotic drug effects is at the receptor level, distal
from the neural system effects that mediate their clinical efficacy. Studying cerebral function …