Direct delivery to the lung via inhalation is arguably one of the most logical approaches to
treat lung cancer using drugs. However, despite significant efforts and investment in this …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Pulmonary delivery of therapeutics is attractive due to rapid absorption and non-
invasiveness but it is challenging to monitor and quantify the delivered aerosol or powder …

Abstract Stone, HB, Moulder, JE, Coleman, CN, Ang, KK, Anscher, MS, Barcellos-Hoff, MH,
Dynan, WS, Fike, JR, Grdina, DJ, Greenberger, JS, Hauer-Jensen, M., Hill, RP, Kolesnick …

Background Evidence shows ionizing radiation can cause lung cancer, but few studies have
quantified risk in relation to radiation dose. Purpose This study evaluated the longtrem risk of …

The mediastinal tissues which included heart, lung, trachea and esophagus of 70 adult
beagle dogs were irradiated to a range of total radiation doses between 24 and 68 Gy given …

Purpose The aim of this study was to determine whether a neutralizing transforming growth
factor–β (TGFβ) antibody can prevent radiation (RT) induced lung injury. Methods and …

1. This Appendix sets out the essential findings of the clinical observation of a group of
patients suffering from acute radiation sickness following the accident at the Chernobyl …

PURPOSE: To test whether a cyclooxygenase-2 inhibitor (celecoxib) could reduce mortality
resulting from radiation-induced pneumonitis. METHODS AND MATERIALS: Celecoxib was …

Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis
following thoracic irradiation remain poorly understood. Here, we hypothesize that …