Objective Advancements in oncologic therapy have increased long-term survival rates for
children with childhood cancers. As survival has increased, the secondary effects of …

Fertility preservation is the process of saving gametes, embryos, gonadal tissues and/or
gonadal cells for individuals who are at risk of infertility due to disease, medical treatments …

Background Testicular tissue freezing is proposed for fertility preservation to (pre) pubertal
boys with cancer before highly gonadotoxic treatment. Studies accurately comparing human …

Introduction Cryopreservation of testicular tissue (TT) has become an increasingly attractive
option for fertility preservation (FP), particularly for pre-pubertal boys at risk for …

Transplantation of own cryostored spermatogonial stem cells (SSCs) is a promising
technique for fertility restoration when the SSC pool has been depleted. In this regard …

Cryopreservation of testicular cells and tissues is useful for the preservation and restoration
of fertility in pre-pubertal males expecting gonadotoxic treatment for cancer and genetic …

Objective To normalize age-dependent effects on standardized measures of spermatogonial
quantity such as the number of spermatogonia per tubular cross-section (S/T) or fertility …

Background Experimental fertility preservation programs have been started to safeguard the
future fertility of prepubertal and pubertal males requiring high‐risk gonadotoxic treatment …

Spermatogenesis is a highly complicated process which initiated by spermatogonial stem
cells (SSCs). SSCs are the only cell type that can restore fertility in infertile recipient after …

STUDY QUESTION Is the protein expression window during testicular development affected
in prepubertal patients at risk for stem cell loss? SUMMARY ANSWER Nuclear ubiquitin …