This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

Genetically modified mice have been studied for more than fifteen years as models of cystic
fibrosis (CF). The large amount of experimental data generated illuminates the complex …

Abstract p73 (ref.) has high homology with the tumour suppressor p53 (refs,,), as well as with
p63, a gene implicated in the maintenance of epithelial stem cells,,. Despite the localization …

Abstract T7 DNA polymerase, catalyses DNA replication in vitro at rates of more than 100
bases per second and has a 3′→ 5′ exonuclease (nucleotide removing) activity at a …

Animal models of cystic fibrosis (CF) are powerful tools that enable the study of the
mechanisms and complexities of human disease. Murine models have several intrinsic …

Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a diverse family of
pattern recognition receptors that are essential mediators of inflammation and host defense …

Airway epithelia are positioned at the interface between the body and the environment, and
generate complex signaling responses to inhaled toxins and other stresses. Luminal …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Animal models of acute and chronic infection, along with mice genetically modified for the
Cftr gene, are a key asset in cystic fibrosis (CF) research. Despite some limitations, these …

Animal models of cystic fibrosis, in particular several different mutant mouse strains obtained
by homologous recombination, have contributed considerably to our understanding of CF …