[HTML][HTML] Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

M Entezari, M Ghanbarirad, A Taheriazam… - Biomedicine & …, 2022 - Elsevier
Among the different kinds of tumors threatening human life, lung cancer is one that is
commonly observed in both males and females. The aggressive behavior of lung cancer …

Drug resistance mechanisms and progress in the treatment of EGFR‑mutated lung adenocarcinoma

R Sun, Z Hou, Y Zhang, B Jiang - Oncology Letters, 2022 - spandidos-publications.com
According to global cancer data, lung cancer was the leading cause of cancer‑related death
in 2020. With the diversification of treatment strategies, the survival outcomes of patients with …

Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer

Z Sirhan, R Alojair, A Thyagarajan, RP Sahu - Pharmaceutics, 2023 - mdpi.com
Lung cancer remains one of the major human malignancies affecting both men and women
worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent type. Multiple …

[HTML][HTML] Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer

JY Lee, RR Bhandare, SHS Boddu, AB Shaik… - Biomedicine & …, 2024 - Elsevier
Tumour suppressor genes play a cardinal role in the development of a large array of human
cancers, including lung cancer, which is one of the most frequently diagnosed cancers …

miR-338-3p blocks TGFβ-induced myofibroblast differentiation through the induction of PTEN

AR Rackow, JL Judge, CF Woeller… - … of Physiology-Lung …, 2022 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease. The pathogenesis of
IPF is not completely understood. However, numerous genes are associated with the …

EGFR amplification is a putative resistance mechanism for NSCLC–LM patients with TKI therapy and is associated with poor outcome

H Yang, L Wen, C Zhao, X Li, C Shan, D Liu… - Frontiers in …, 2022 - frontiersin.org
Background Leptomeningeal metastases (LM) have become increasingly common in non-
small cell lung cancer (NSCLC) patients who harbor epidermal growth factor receptor …

Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer

Y Wang, T Zhang, X He - Frontiers in Oncology, 2023 - frontiersin.org
Cancer has long been a topic of great interest in society and a major factor affecting human
health. Breast, prostate, lung, and colorectal cancers are the top four tumor types with the …

ERBB and P-glycoprotein inhibitors break resistance in relapsed neuroblastoma through P-glycoprotein

L Rösch - 2023 - archiv.ub.uni-heidelberg.de
Neuroblastoma is a pediatric tumor of the sympathetic nervous system that most commonly
affects infants and young children. It is a disease with very variable outcomes, which range …

BRD9 Inhibition Overcomes Epithelial to Mesenchymal Transition-Associated Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer

H Calkins - 2023 - search.proquest.com
Advanced lung cancer patients that present with activating mutations in the epidermal
growth factor receptor (EGFR) are treated with EGFR tyrosine kinase inhibitors (EGFR TKIs) …

[PDF][PDF] Mecanismos de resistência aos inibidores da tirosina cinase do recetor do fator de crescimento epidérmico no cancro de pulmão de não pequenas células

SC Bastos - 2022 - repositorio-aberto.up.pt
Introdução: Apesar dos avanços científicos que ocorreram na última década, o cancro do
pulmão continua a ser a principal causa de morte relacionada com cancro em todo o …