Rationale APP23 mice are a promising model of Alzheimer's disease, expressing several
histopathological, cognitive and behavioural hallmarks of the human condition. A valid …

OBJECTIVES Prospectively collected computer database information was previously
assessed on a cohort of 300 patients who fulfilled the Copenhagen classification criteria for …

Nicotine has been shown in a variety of studies to improve cognitive function including
learning, memory and attention. Nicotine both stimulates and desensitizes nicotinic …

Nicotine has been demonstrated to enhance learning processes. The present experiments
extend these results to examine the effects of nicotine on acquisition and consolidation of …

Noninvasive imaging of nicotinic acetylcholine receptors (nAChRs) in the human brain in
vivo is critical for elucidating the role of these receptors in normal brain function and in the …

Impairment of the central cholinergic system has a pivotal role in the cognitive decline
observed in patients with Alzheimer's disease (AD). One of the most prominent cholinergic …

To study the immunological effects of nicotine, there are several rodent models for chronic
nicotine administration. These models include subcutaneously implanted miniosmotic …

There is increasing evidence that some lifestyle factors are linked to the development of
Alzheimer's disease. Many of these are potentially modifiable and include smoking, physical …

Patients with schizophrenia exhibit deficits in a range of cognitive functions, particularly
working and episodic memory, which are thought to be core features of the disorder …

Discovery of the important role played by nicotinic acetylcholine receptors (nAChRs) in
several CNS disorders has called attention to these membrane proteins and to ligands able …