Agonists of the a4b2 nicotinic acetylcholine receptors have been synthesised as potential
drugs for treatment of a variety of diseases. In this review, the published nicotinic agonists …

Chronic nicotine administration has been shown to significantly improve working memory.
Nicotinic involvement in memory function critically involves the ventral hippocampus. Local …

Objective: To examine patterns of familial aggregation and factors influencing onset age in a
sample of siblings with PD. Methods: Sibling pairs (n= 203) with PD were collected as part of …

Almost all alcoholics (80%–95%) smoke tobacco. When alcoholics binge, they achieve high,
sustained blood alcohol levels, become physically dependent, and often suffer loss of …

An individual, goal-oriented cognitive rehabilitation intervention was conducted with AB, a
77-year-old woman with MCI. Outcomes were evaluated using a client-centred measure of …

Neurofibrillary lesions and senile plaques that are composed mainly of
hyperphosphorylated tau protein and the amyloid-β peptide derived from the amyloid …

The recent use of genetically engineered knockout (Ko) and knockin (Kin) animals for
neurotransmitter receptor genes, in particular, nicotinic acetylcholine receptors (nAChRs) in …

The α-conotoxin MII is a two disulfide bridge containing, 16 amino acid long peptide toxin
isolated from the marine snail Conus magus. This toxin has been found to be a highly …

The brain remains an area where little corrective surgery can be performed and the reversal
of damage is almost impossible. Recently, reports of agents offering neuroprotection have …

Recent studies have reported that the" cholinergic anti-inflammatory pathway" regulates
peripheral inflammatory responses via α 7 nicotinic acetylcholine receptors (α 7 nAChRs) …