Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

F Eskandari-Malayeri, M Rezaei - Frontiers in Immunology, 2022 - frontiersin.org
The tumor microenvironment (TME) is a significant contributor to cancer progression
containing complex connections between cellular and chemical components and provides a …

The multiple layers of the tumor environment

L Laplane, D Duluc, N Larmonier, T Pradeu, A Bikfalvi - Trends in cancer, 2018 - cell.com
The notion of tumor microenvironment (TME) has been brought to the forefront of recent
scientific literature on cancer. However, there is no consensus on how to define and spatially …

Novel design of multifunctional nanozymes based on tumor microenvironment for diagnosis and therapy

X Zhu, N Xu, L Zhang, D Wang, P Zhang - European Journal of Medicinal …, 2022 - Elsevier
Nanozymes have entranced considerable concern since they provide a likelihood strategy
for performing the integration of diagnosis and therapy. Nanozymes, as emerging …

Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer

Y Lin, X Pan, L Zhao, C Yang, Z Zhang, B Wang… - NPJ Genomic …, 2021 - nature.com
Increasing evidence has clarified that the tumor microenvironment (TME) is closely related to
the prognosis and therapeutic efficacy of cancer. However, there is no reliable TME …

Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects

G Deng, X Zhang, Y Chen, S Liang, S Liu, Z Yu… - Frontiers in …, 2023 - frontiersin.org
Gastric cancer is one of the most serious malignant tumor and threatens the health of people
worldwide. Its heterogeneity leaves many clinical problems unsolved. To treat it effectively …

Three-dimensional 3D culture models in gynecological and breast cancer research

YM Salinas-Vera, J Valdes, Y Perez-Navarro… - Frontiers in …, 2022 - frontiersin.org
Traditional two-dimensional (2D) monolayer cell cultures have long been the gold standard
for cancer biology research. However, their ability to accurately reflect the molecular …

Recent advances in silver nanozymes: concept, mechanism, and applications in detection

S Mishra, A Abdal‐hay, SU Rather… - Advanced Materials …, 2022 - Wiley Online Library
Natural enzymes accelerate substrate‐specific reactions making them of exquisite interest
for various applications. However, their appeal is lost in a practical setting due to low stability …

Chronic cancer pain: opioids within tumor microenvironment affect neuroinflammation, tumor and pain evolution

A Santoni, M Santoni, E Arcuri - Cancers, 2022 - mdpi.com
Simple Summary Pain is a worrisome symptom that 60–80% of patients with cancer
experience chronically. In the last twenty years, immunological and pain research have …

Clear‐Box Machine Learning for Virtual Screening of 2D Nanozymes to Target Tumor Hydrogen Peroxide

XJ Gao, J Yan, JJ Zheng, S Zhong… - Advanced Healthcare …, 2023 - Wiley Online Library
Targeting tumor hydrogen peroxide (H2O2) with catalytic materials has provided a novel
chemotherapy strategy against solid tumors. Because numerous materials have been …

A covalent organic framework-based multifunctional therapeutic platform for enhanced photodynamic therapy via catalytic cascade reactions

L Cai, C Hu, S Liu, Y Zhou, M Pang, J Lin - Sci China Mater, 2020 - hero.epa.gov
Utilizing the unique tumor microenvironment (TME) to conduct chemical reactions for cancer
treatment becomes a hot topic recently. Nevertheless, single chemical reaction in TME is …