Islet transplantation is a well-established therapeutic treatment for a subset of patients with
complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Human bone marrow mesenchymal stem cells (hBMSCs) and their exosomes can suppress
immune reaction and deliver small RNAs. Thus, they may improve islet transplantation by …

Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal
capacity and differentiation potential into several mesenchymal lineages including bones …

Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …

The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

Diabetes remains a devastating disease, with tremendous cost in terms of human suffering
and healthcare expenditures. A bioartificial pancreas has the potential as a promising …

Among various synthetic gene carriers currently in use, liposomes composed of cationic
lipids and co-lipids remain the most efficient transfection reagents. Physicochemical …